Recent Publications

2026

• Shlossman M, Cook DP. Refueling T cell memory in cystic fibrosis. *Am J Respir Cell Mol Biol.* 2026 May 11. Doi: 10.1093/ajrcmb/aanag060 PMID: 42113901.
• Cooney AL, Thornell IM, Pezzulo AA, Fischer AJ, Cook DP, et al.; Meyerholz DK. Considerations for early life genetic therapies in cystic fibrosis. *Am J Physiol Lung Cell Mol Physiol.* 2026 Apr 29. PMID 42053522.
• Rusznak M, Toki S, Hao Y, et al.; Cook DP, Newcomb DC, Zou F, Peebles RS Jr. Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming. *Nat Commun.* 2026 Jan 3;17(1):1053. PMID 41484153.

2025

• Zhou W, Zhang J, Chowdhury NU, Norlander AE, Toki S, Abney M, Rusznak M, Gibson-Corley KN, Cook DP, Newcomb DC, Peebles RS Jr. PGI2 signaling metabolically reprograms CD4 Th2 cells and represses allergic airway inflammation. J Immunol. 2025 Sep 1;214(9):2270-2280. doi: 10.1093/jimmun/vkaf130. PMID: 40587812; PMCID: PMC12481032.
• Zhou W, Zhang J, Norlander AE, Cook DP, Toki S, Abney M, Rusznak M, Thomas C, Warren C, Richmond BW, Gibson-Corley K, Milne GL, Newcomb DC, Peebles RS Jr. PGI2 restricts trained ILC2 responses in allergic inflammation. J Immunol. 2025 Jul 1;214(7):1582-1591. doi: 10.1093/jimmun/vkaf088. PMID: 40334085; PMCID: PMC12311380.
• Rusznak M, Thomas CM, Zhang J, Toki S, Zhou W, Abney M, Yanda DM, Norlander AE, Hodges CA, Newcomb DC, Kaplan MH, Peebles RS Jr, Cook DP. CFTR negatively reprograms Th2 cell responses, and CFTR potentiation restrains allergic airway inflammation. JCI Insight. 2025 Mar 25;10(9):e191098. doi: 10.1172/jci.insight.191098. PMID: 40131363; PMCID: PMC12128969.
• Cook DP, Peebles RS Jr. The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation. Immunol Rev. 2025 Mar;330(1):e70009. doi: 10.1111/imr.70009. PMID: 39981881; PMCID: PMC11843850.
• Rhee KY, Emala CW, Gallagher EJ, Rockey DC, Hu PJ, Vyas JM, Cook DP, Scharschmidt TC, Ajijola OA; ASCI Research Pathways Working Group; Williams CS. Paving the physician-scientist career path: from grassroots gathering to national forum. JCI Insight. 2025 Apr 8;10(7):e192689. doi: 10.1172/jci.insight.192689. PMID: 40197362; PMCID: PMC11981613.
• Cook DP, Peebles RS Jr. Chapter 26: Hypersensitivity (Type IV). Immunology. 2025. 10^th edition; Saunders Elsevier, Philadelphia, PA.

2024

• Cook DP, Wu AY, Thomas CM, Hamilton RG, Peebles RS Jr, Kerchberger VE. Type 2 inflammation in cystic fibrosis is a predictor of mortality and targeted with CFTR modulator therapy. *Allergy.* 2024 Dec;79(12):3528–3533. PMID 38881035.

2023

• Cook DP, Thomas CM, Wu AY, et al.; Stoltz DA, Peebles RS Jr. Cystic fibrosis reprograms airway epithelial IL-33 release and licenses IL-33–dependent inflammation. *Am J Respir Crit Care Med.* 2023 Jun 1;207(11):1486–1497. PMID 36952660.

2022

• Cook DP, Peebles RS Jr. A Nod and a WNK (kinase): understanding airway surface liquid pH. *Am J Respir Cell Mol Biol.* 2022 Oct;67(4):421–422. (Editorial) PMID 35881960.
• Cook DP, Xu M, Martucci VL, et al.; Brittain EL. Clinical insights into pulmonary hypertension in chronic obstructive pulmonary disease. *Pulm Circ.* 2022 Jan;12(1):e12006. PMID 35506103.
• Book chapter: Cook DP, Stoltz DA. *Model Organisms of Cystic Fibrosis.* CRC Press, Boca Raton, FL. 5th ed., 2022

2021

• Bouzek DC, Abou Alaiwa MH, Adam RJ, et al.; Cook DP, et al.; Stoltz DA. Early lung disease exhibits bacteria-dependent and -independent abnormalities in cystic fibrosis pigs. *Am J Respir Crit Care Med.* 2021 Sep 15;204(6):692–702. PMID 34170795.

2020

• Ram-Mohan S, Bai Y, Schaible N, et al.; Cook DP, et al.; Krishnan R. Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices. *Am J Physiol Lung Cell Mol Physiol.* 2020 Feb 1;318(2):L323–L330. PMID 31774304.

2018

• Meyerholz DK, Stoltz DA, Gansemer ND, et al.; Cook DP, et al.; McCray PB Jr. Lack of CFTR disrupts fetal airway development in pigs. *Lab Invest.* 2018 Jun;98(6):825–838. PMID 29467455.

2017

• Cook DP, Adam RJ, Zarei K, et al.; Stoltz DA. CF airway smooth muscle transcriptome reveals a role for PYK2. *JCI Insight.* 2017 Sep 7;2(17). PMID 28878137.
• Adam RJ, Abou Alaiwa MH, Bouzek DC, Cook DP, et al.; Stoltz DA. Postnatal airway growth in cystic fibrosis piglets. *J Appl Physiol.* 2017 Sep 1;123(3):526–533. PMID 28620056.
• Ostedgaard LS, Moninger TO, McMenimen JD, et al.; Cook DP, et al.; Welsh MJ. Gel-forming mucins form distinct morphologic structures in airways. *Proc Natl Acad Sci USA.* 2017 Jun 27;114(26):6842–6847. PMID 28607090.
• Cook DP, Adam RJ, Abou Alaiwa MH, et al.; Stoltz DA. Mounier-Kuhn syndrome: a case of tracheal smooth muscle remodeling. *Clin Case Rep.* 2017 Feb;5(2):93–96. PMID 28174630.

2016

• Cook DP, Rector MV, Bouzek DC, et al.; Stoltz DA. Cystic fibrosis transmembrane conductance regulator in sarcoplasmic reticulum of airway smooth muscle: implications for airway contractility. *Am J Respir Crit Care Med.* 2016 Feb 15;193(4):417–426. PMID 26488271.